Chronic Cough Study

Refractory or Unexplained Chronic Cough is a persistent cough that lasts longer than eight weeks and can occur when no clear cause is found. It affects millions of people worldwide and often continues despite treatment for conditions such as asthma, reflux or infections. 

People living with chronic cough may experience frequent coughing fits that disrupt sleep, speech, and daily life, sometimes leading to anxiety and social withdrawal. Although chronic cough isn’t life threatening, it can severely affect physical comfort and emotional well-being. 

Current treatment for chronic cough focus on managing potential underlying causes, but they often do not relieve symptoms and the cough remains persist. That’s why new approaches are urgently needed.

In recent years, research has shifted toward targeting the nerve pathways that trigger coughing. This study is investigating a medication that works by blocking the nerve receptors thought to trigger coughing. The goal is to reduce cough frequency and severity by calming the overactive cough reflux. 

By joining this study, you’ll contribute to research exploring whether the investigational medicine can offer meaningful relief for individuals living with chronic cough.

Participants in this study will be randomly assigned to receive the investigational medication or a placebo.

During the initial 24-week phase, you’ll take the randomly assigned medication twice daily and attend regular clinic visits for health assessments and cough monitoring. 

If you complete this phase, you may enter the 28-week open-label extension, where all participants will receive the investigational medication. 

As part of the study, you will also be asked to wear a 24-hour ambulatory cough recorder. This small, wearable device tracks how often you cough throughout the day and night, allowing researchers to understand how the treatment is working.

Why join a clinical research study?

- Gain early access to new potential treatments at no cost

- Contribute to research that could improve the lives of others living with Chronic Cough

- Learn to better manage your condition

- Receive health checks and advice from our professional medical team

Your privacy is important. All personal information will be kept strictly confidential.

Register your interest today.