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Mixed Hyperlipidemia Studies Auckland
Marigold Mixed Hyperlipidemia Study
Auckland
We are looking for adults aged 18 years and older who have mixed hyperlipidaemia, meaning high triglycerides and high LDL-cholesterol or non-HDL cholesterol.
Description
What to expect
Study details
Ages
18 years or older
Duration
12-14 clinic visits over 41 weeks **may include two 24-hour clinic stays (depending on study groups)
Compensation
You will be reimbursed for your time and travel costs
Eligibility Criteria
- Adults aged 18+ with high cholesterol
- Diagnosed or suspected mixed hyperlipidaemia
- Fasting triglycerides ≥150 mg/dL
- LDL-C ≥70 mg/dL OR non-HDL-C ≥100 mg/dL
- Willing to maintain stable medications and diet
- Not pregnant or breastfeeding
- Able to attend visits over several months
Locations
Description
Mixed hyperlipidaemia means having high cholesterol and high triglycerides, both of which increase the risk of heart disease. Standard treatments in New Zealand include lifestyle changes, statins, fibrates, omega-3 fatty acids, and dietary modification. Despite current treatments, many people continue to have elevated lipid levels. There is a need for better treatments and medications for people with high cholesterol and high triglycerides.
About the investigational medication
The investigational medication is a new RNA interference (RNAi) administered as a subcutaneous injection medication designed to lower both:
- PCSK9 – a protein that increases LDL cholesterol
- APOC3 – a protein that increases triglycerides
It aims to work by reducing the production of these proteins in the liver, which may help lower cholesterol and triglycerides.
What to expect
Reason to participate
Your involvement may help researchers learn more about new treatments that could support people with high cholesterol and triglycerides in the future. Although you may not personally benefit, your participation contributes to medical research. Other reasons to participate include:
- Regular health monitoring by highly experienced NZ Doctors and Nurses
- Study care and medication are provided free of charge
- Compensation for your time and travel expenses
About The Study
During visits, we conduct health checks that may include physical examinations and blood tests. We would like to ask you questions about your health and learn about your experience taking this medication. Other procedures may include:
- Height/Weight/BMI
- ECG’s
- Drug screening
- Hepatitis/HIV screening
- Dietary counselling
- Vital signs, urine samples, and fasted blood tests
- Subcutaneous injection of the study drug
- Biomarker sampling (if applicable)
- Pregnancy testing (if applicable)
You would take the potential new medication or a placebo (looks like the investigational medicine but contains no active medication). About 75% of participants will receive the active study drug, and 25% will receive the placebo.
The study medication is administered as a subcutaneous injection (meaning it is injected under the skin with a very small needle, like common diabetes medications).
The study aims to investigate the study drug and determine whether it can successfully lower cholesterol, lipids, and triglycerides, and improve participants' general health markers.
Apply now
Fill out your details, and our team will be in touch to discuss your potential involvement in this study and answer any questions you may have.
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