Takahē Type 2 Diabetes & Overweight Study

About the Condition

Obesity and Type 2 diabetes often occur together and can increase the risk of heart disease, stroke, and other health conditions. Healthy eating, physical activity, and medications can help manage these conditions, but many people continue to struggle with weight and blood sugar control.

Current treatments available in New Zealand include metformin and other oral diabetes medications, GLP-1 receptor agonists, SGLT-2 inhibitors, and lifestyle-based approaches. This study is testing whether a new investigational medication may offer another option in the future.

About the Investigational Medication 

The investigational medication is a dual GLP-1 and GIP receptor agonist, similar to newer injectable diabetes and weight-management medications available overseas. It acts on hormones that help:

• Reduce appetite
• Improve insulin sensitivity
• Lower blood glucose
• Support weight loss

About The Study

Taking part in the study involves firstly meeting with the research Doctor to find out more about your health and to see if the study is right for you. If you wish to take part and are eligible, we would like to see you for 15 clinic visits and 7 virtual visits over 84 weeks. During visits, we conduct health checks that may include physical examinations and blood tests. We would like to ask you questions about your health and your experience taking the study medication throughout the study.

Other procedures may include:

• ECG
• Questionnairess
• Weight and waist measurements
• Review of glucose readings
• Self-injection training
• Diabetes education and nutritional counselling

You would take the potential new medication or a placebo (looks like the investigational medicine but contains no active medication). 29% of participants will receive a placebo, meanwhile 71% will receive the study drug.

The study medication is given once weekly as a small injection under the skin (abdomen). Participants self-inject after training.

Why Join this Clinical Research Study?

Taking part may help advance scientific knowledge and contribute to the development of new treatment options for people with obesity and diabetes in the future.

Other reasons to participate:

• Health monitoring by highly specialised NZ Doctors and Nurses
• Study care and medication are provided free of charge
• Participants were compensated for their time and travel
• If eligible, all participants will receive dietician support

Your privacy is important, and all personal information will be kept strictly confidential.